Surfactant selection via HLD-based webapp

The predictive formulation science Hydrophilic Lipophilic Difference (HLD), is a very powerful tool to match surfactants with a given oil/oil blend, resulting in maximum overall performance of emulsions, while minimizing development time. It can also be used to replace surfactants and oils, or find ingredients to make them compatible. HLD gives a predictive parameter to a wide variety of surfactants and oils, applicable to develop personal and home care, resin emulsions, etc. The ingredient parameter can be used repeatedly and it drastically reduce experimental work, time and costs, which makes it a more sustainable R&D workflow. VLCI established the world’s largest shared HLD dataset of commercial ingredients, which is linked to the HLD-based webapp PrediMulsion, to visualize and perform searches based on calculations. The collaborative framework of the platform allows to add and share ingredient HLD parameters, when needed, while securing each users own private datasets, formulations and IP. The HLD determinations are performed via a High Throughput workflow, to further scale the shared dataset in collaboration with the formulation industry, which will be explained during the presentation. Also, features of PrediMulsion will be presented, including examples of assisted final product formulations, to showcase how this can achieve a 100x faster selection of surfactants and narrow down formulation space a 10-fold.