Advanced Methods of Analysis, Including Lipidomics

Session Chair(s)

• 

  William Byrdwell, PhD, FAOCS (he/him/his)

  Research Chemist
  Methods and Application of Food Composition Lab
  USDA ARS BHNRC MAFCL
  Beltsville, MD, United States
• BY

  Baoru Yang

  PhD, Professor
  Food Sciences, Department of Life Technologies
  University of Turku, Finland

Modern lipid analysis is based on liquid chromatography-mass spectrometry (LC-MS) using both online and offline tools. Identification of regioisomers, lipids with the fatty acids located on specific positions of the glycerol backbones, continues to be an important component of complete structural analysis of phospholipids and triacylglycerols. Since digestion of lipids is regiospecific, an understanding of the structures of regioisomers allows the correlation of components of a diet to the dietary response. This session provides presentations describing the latest technology applied to regioisomer analysis.
These days, artificial intelligence, machine learning, and R code play increasingly important roles in data analysis. This session includes presentations on the use of R for quantitative analysis of triacylglycerols, and for machine learning approaches in preclinical and clinical studies using the R caret package to reveal intricate connections between lipid metabolism and clinically measured outcomes.

Presentations:

• 10:35 AM – 10:55 AM EDT

  High Throughput Analysis of Tissue Phosphatidylcholines Revealing Comprehensive Regioisomer Profiles and Their Response to Diet
  

  Presenting Author: Baoru Yang (she/her/hers) – University of Turku

  Co-Author: yuqing Zhang – University of Turku

  Co-Author: Pontus Boström (he/him/his) – University of Turku

  Co-Author: Yumei Zhang – Peking University

  Co-Author: Haraldur Gunnar Guðmundsson – University of Iceland

  Co-Author: Guðmundur Gunnar Haraldsson – University of Iceland

  Co-Author: Mikael Fabritius, PhD (he/him/his) – University of Turku
• 10:55 AM – 11:15 AM EDT

  Comprehensive analysis of triglycerides and their regioisomers in different plant oils based on UPLC-EAD-MS/MS and feature fragment ions database
  

  Co-Author: Zuojian Qin – Oil Crops Research Institute Of Chinese Academy Of Agricultural Sciences

  Co-Author: Xin Lv – Oil Crops Research Institute Of Chinese Academy Of Agricultural Sciences

  Co-Author: Hong Chen, PhD (he/him/his) – Oil Crops Research Institute

  Presenting Author: Fang Wei, PhD – Oil Crop Research Institue, Chinese Academy of Agricural Sciences
• 11:15 AM – 11:35 AM EDT

  An interactive R-based open-source solution for qualitative and quantitative lipidomics of bovine milk
  

  Presenting Author: William C. Byrdwell, PhD, FAOCS (he/him/his) – USDA ARS BHNRC MAFCL
• 11:35 AM – 11:55 AM EDT

  Machine learning based approaches using lipidomics in preclinical and clinical studies using the R Statistical Language.
  

  Presenting Author: Brian D. Piccolo, PhD – Arkansas Children's Nutrition Center